A novel and versatile design of DNA–lipid conjugates is presented. The assembly of the DNA headgroups into G-quadruplex structures is essential for the formation of micelles and their stability. By hybridization with a complementary oligonucleotide the micelles were destabilized, resulting in cargo release. In combination with a hairpin DNA aptamer as complementary strand, the release is obtained selectively by the presence of ATP.
L. Cozzoli, L. Gjonaj, M. C. A. Stuart, B. Poolman and G. Roelfes, Chem. Commun., 2018, 54, 260 DOI: 10.1039/C7CC07899D
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