Issue 61, 2018

Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides

Abstract

This study assessed the effects of artificial cationic oligopeptides on a DNA/RNA hybrid duplex. An oligopeptide containing the octamer of L-2,4-diaminobutyric acid (Dab8) was found to enhance both the RNase A resistance and RNase H activity of the DNA/RNA hybrid, which are important for developing nucleic acid drugs.

Graphical abstract: Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
22 May 2018
Accepted
05 Jul 2018
First published
06 Jul 2018

Chem. Commun., 2018,54, 8526-8529

Author version available

Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides

R. I. Hara, Y. Maeda, H. Fujimaki and T. Wada, Chem. Commun., 2018, 54, 8526 DOI: 10.1039/C8CC04082F

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