Issue 52, 2018

Reductive coupling of two aldehydes to unsymmetrical E-alkenes via phosphaalkene and phosphinate intermediates

Abstract

Stilbenes with push–pull electronics are directly accessible from an electron-rich and an electron-deficient benzaldehyde in a novel reductive aldehyde cross-coupling reaction. The one-pot procedure is enabled by the oxidation of a transient phosphinite to the corresponding phosphinate which exhibits sufficient reactivity towards deactivated aldehydes.

Graphical abstract: Reductive coupling of two aldehydes to unsymmetrical E-alkenes via phosphaalkene and phosphinate intermediates

Supplementary files

Article information

Article type
Communication
Submitted
27 May 2018
Accepted
01 Jun 2018
First published
11 Jun 2018
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2018,54, 7163-7166

Reductive coupling of two aldehydes to unsymmetrical E-alkenes via phosphaalkene and phosphinate intermediates

J. Mai, A. I. Arkhypchuk, A. K. Gupta and S. Ott, Chem. Commun., 2018, 54, 7163 DOI: 10.1039/C8CC04218G

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