Issue 72, 2018

Topology- and linking number-controlled synthesis of a closed 3 link chain of single-stranded DNA

Abstract

In spite of remarkable progress in synthetic methodology, a closed three-link chain (one of the simplest but the most important topological isomers of [3]catenane) has never been prepared. Here we synthesized this isomer in high yield from three oligonucleotides which are designed to optimize various chemical and steric factors in their mutual hybridization.

Graphical abstract: Topology- and linking number-controlled synthesis of a closed 3 link chain of single-stranded DNA

Supplementary files

Article information

Article type
Communication
Submitted
21 Jun 2018
Accepted
15 Aug 2018
First published
16 Aug 2018

Chem. Commun., 2018,54, 10156-10159

Topology- and linking number-controlled synthesis of a closed 3 link chain of single-stranded DNA

Q. Li, G. Wu, Y. Yang, R. An, J. Li, X. Liang and M. Komiyama, Chem. Commun., 2018, 54, 10156 DOI: 10.1039/C8CC04965C

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