Issue 72, 2018

Reductive cyclisations of amidines involving aminal radicals

Abstract

Amidines bearing simple alkenes undergo aminal radical cyclisation upon treatment with SmI2. The mild, reductive electron transfer process delivers medicinally-relevant, polycyclic quinazolinone derivatives in good to excellent yield and typically with complete diastereocontrol.

Graphical abstract: Reductive cyclisations of amidines involving aminal radicals

Supplementary files

Article information

Article type
Communication
Submitted
28 Jun 2018
Accepted
14 Aug 2018
First published
15 Aug 2018

Chem. Commun., 2018,54, 10160-10163

Reductive cyclisations of amidines involving aminal radicals

H. Huang, R. W. Adams and D. J. Procter, Chem. Commun., 2018, 54, 10160 DOI: 10.1039/C8CC05178J

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