Issue 7, 2018
From the journal:

Organic Chemistry Frontiers

Synthesis of chiral sultams with two adjacent stereocenters via palladium-catalyzed dynamic kinetic resolution†

Bo Song, ORCID logo a   Mu-Wang Chen ORCID logo a  and  Yong-Gui Zhou ORCID logo *ab  

* Corresponding authors

a State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China
E-mail: ygzhou@dicp.ac.cn
Web: http://www.lac.dicp.ac.cn/

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China

Abstract

A palladium-catalyzed intramolecular asymmetric reductive amination of racemic α-branched ketones bearing the poorly nucleophilic sulfonamides has been successfully developed through dynamic kinetic resolution, providing chiral δ-sultams with two contiguous stereogenic centers with high diastereoselectivity and enantioselectivity.

Graphical abstract: Synthesis of chiral sultams with two adjacent stereocenters via palladium-catalyzed dynamic kinetic resolution

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Article information

DOI
https://doi.org/10.1039/C7QO01098B
Article type
Research Article
Submitted
06 Dec 2017
Accepted
16 Jan 2018
First published
16 Jan 2018

Org. Chem. Front., 2018,5, 1113-1117

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Synthesis of chiral sultams with two adjacent stereocenters via palladium-catalyzed dynamic kinetic resolution

B. Song, M. Chen and Y. Zhou, Org. Chem. Front., 2018, 5, 1113 DOI: 10.1039/C7QO01098B

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