Issue 87, 2019
From the journal:

Chemical Communications

Assembly of branched ubiquitin oligomers by click chemistry†

Xiaohui Zhao,a   Martin Scheffner ORCID logo *a  and  Andreas Marx ORCID logo *a  

* Corresponding authors

a Departments of Chemistry and Biology, Konstanz Research School Chemical Biology, University of Konstanz, 78457 Konstanz, Germany
E-mail: andreas.marx@uni-konstanz.de, martin.scheffner@uni-konstanz.de

Abstract

Ubiquitin monomers functionalized with an azide or multiple alkynes were utilized for the assembly of branched ubiquitin oligomers (K6/K11, K11/K48, K11/K63, K6/K11/K48) by click chemistry. The oligomers resist deubiquitylase-catalysed hydrolysis and exhibit stability in eukaryotic cell lysates.

Graphical abstract: Assembly of branched ubiquitin oligomers by click chemistry

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Article information

DOI
https://doi.org/10.1039/C9CC07303E
Article type
Communication
Submitted
17 Sep 2019
Accepted
09 Oct 2019
First published
09 Oct 2019

Chem. Commun., 2019,55, 13093-13095

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Assembly of branched ubiquitin oligomers by click chemistry

X. Zhao, M. Scheffner and A. Marx, Chem. Commun., 2019, 55, 13093 DOI: 10.1039/C9CC07303E

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