Issue 10, 2019
From the journal:

Organic Chemistry Frontiers

Synthesis of chiral seven-membered cyclic sulfonamides through palladium-catalyzed arylation of cyclic imines†

Zi-Biao Zhao, ORCID logo ab   Lei Shi, ORCID logo *a   Fan-Jie Meng,a   Yaming Lia  and  Yong-Gui Zhou ORCID logo *ab  

* Corresponding authors

a State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, 2 Linggong Road, Dalian 116024, P. R. China
E-mail: shileichem@dlut.edu.cn

b State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China
E-mail: ygzhou@dicp.ac.cn

Abstract

An enantioselective palladium-catalyzed addition of arylboronic acids to seven-membered cyclic N-sulfonyl aldimines and ketimines has been developed, giving the chiral cyclic sulfonamides with excellent yields and up to 99% ee.

Graphical abstract: Synthesis of chiral seven-membered cyclic sulfonamides through palladium-catalyzed arylation of cyclic imines

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Article information

DOI
https://doi.org/10.1039/C8QO01323C
Article type
Research Article
Submitted
08 Dec 2018
Accepted
20 Mar 2019
First published
22 Mar 2019

Org. Chem. Front., 2019,6, 1572-1576

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Synthesis of chiral seven-membered cyclic sulfonamides through palladium-catalyzed arylation of cyclic imines

Z. Zhao, L. Shi, F. Meng, Y. Li and Y. Zhou, Org. Chem. Front., 2019, 6, 1572 DOI: 10.1039/C8QO01323C

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