Issue 10, 2019

Highly efficient enantioselective synthesis of bispiro[benzofuran-oxindole-pyrrolidine]s through organocatalytic cycloaddition

Abstract

A series of compounds featuring novel bispiro[benzofuran-oxindole-pyrrolidine] moieties have been achieved through a thiourea-catalyzed 1,3-dipolar cycloaddition reaction. The Michael/Mannich reaction of N-2,2,2-trifluoroethylisatin ketimines with aurones furnished the cycloadducts in excellent yields with excellent stereoselectivities.

Graphical abstract: Highly efficient enantioselective synthesis of bispiro[benzofuran-oxindole-pyrrolidine]s through organocatalytic cycloaddition

Supplementary files

Article information

Article type
Research Article
Submitted
13 Feb 2019
Accepted
17 Mar 2019
First published
18 Mar 2019

Org. Chem. Front., 2019,6, 1567-1571

Highly efficient enantioselective synthesis of bispiro[benzofuran-oxindole-pyrrolidine]s through organocatalytic cycloaddition

B. Li, F. Gao, X. Feng, M. Sun, Y. Guo, D. Wen, Y. Deng, J. Huang, K. Wang and W. Yan, Org. Chem. Front., 2019, 6, 1567 DOI: 10.1039/C9QO00241C

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