Direct photochemical cross-coupling between aliphatic acids and BF3K salts

Abstract

We describe a novel photoredox hetero-coupling reaction of two C (sp³) radicals from aliphatic acids or BF₃K salts. The kinetic differences in radical persistence provide cross-selectivity, using an organic photoredox catalyst and an oxidant with visible light. This method exhibits broad scope, including several examples constructing sterically hindered C(sp³)–C(sp³) bonds.