Ru(II) photosensitizers competent for hypoxic cancers via green light activation

Francisco J. Ballester; Enrique Ortega; Delia Bautista; M. Dolores Santana; José Ruiz

doi:10.1039/D0CC02417A

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Ru(ii) photosensitizers competent for hypoxic cancers via green light activation†

Francisco J. Ballester,

^a Enrique Ortega,

^a Delia Bautista,

^b M. Dolores Santana

*^a and José Ruiz

*^a

Author affiliations

* Corresponding authors

^a Departamento de Química Inorgánica, Universidad de Murcia, and Biomedical Research Institute of Murcia (IMIB-Arrixaca), E-30071 Murcia, Spain
E-mail: jruiz@um.es, dsl@um.es

^b SAI Universidad de Murcia, E-30071 Murcia, Spain

Abstract

A family of five heteroleptic complexes [Ru(C^N)(N^N)₂][PF₆] (HC^N = methyl 1-butyl-2-arylbenzimidazolecarboxylate; N^N = polypyridine) has been synthesized to act as biologically-compatible green light photosensitizers (PSs) with phototherapeutic indexes (PIs) up to higher than 700 under hypoxia (2% O₂) in HeLa cancer cells under short time of irradiation.

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Article information

DOI: https://doi.org/10.1039/D0CC02417A
Article type: Communication
Submitted: 03 Apr 2020
Accepted: 17 Jul 2020
First published: 17 Jul 2020

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Chem. Commun., 2020,56, 10301-10304

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Ru(II) photosensitizers competent for hypoxic cancers via green light activation

F. J. Ballester, E. Ortega, D. Bautista, M. D. Santana and J. Ruiz, Chem. Commun., 2020, 56, 10301 DOI: 10.1039/D0CC02417A

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Chemical Communications

Ru(ii) photosensitizers competent for hypoxic cancers via green light activation†

Abstract

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Ru(II) photosensitizers competent for hypoxic cancers via green light activation

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