Issue 87, 2021
From the journal:

Chemical Communications

Nickel-catalyzed enantioselective umpolung hydrogenation for stereoselective synthesis of β-amido esters†

Jianrong Steve Zhou, ORCID logo *a   Siyu Guo,b   Xiaohu Zhaob  and  Yonggui Robin Chi ORCID logo b  

* Corresponding authors

a State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Room F312, 2199 Lishui Road, Nanshan District, Shenzhen 518055, China
E-mail: jrzhou@pku.edu.cn

b Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore

Abstract

Nickel complexes ligated by strongly donating diphosphines catalyze enantioselective hydrogenation for the preparation of acyclic and cyclic β-amido esters. A combination of acetic acid and indium powder provides protons and electrons to form nickel hydrido complexes under umpolung hydrogenation conditions.

Graphical abstract: Nickel-catalyzed enantioselective umpolung hydrogenation for stereoselective synthesis of β-amido esters

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Article information

DOI
https://doi.org/10.1039/D1CC05257H
Article type
Communication
Submitted
21 Sep 2021
Accepted
06 Oct 2021
First published
06 Oct 2021

Chem. Commun., 2021,57, 11501-11504

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Nickel-catalyzed enantioselective umpolung hydrogenation for stereoselective synthesis of β-amido esters

J. S. Zhou, S. Guo, X. Zhao and Y. R. Chi, Chem. Commun., 2021, 57, 11501 DOI: 10.1039/D1CC05257H

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