Issue 9, 2022

Cobalt-catalyzed direct α-hydroxymethylation of amides with methanol as a C1 source

Abstract

Herein, we report a cobalt-catalyzed α-hydroxymethylation of amides with methanol under mild conditions. Using CoCl2·6H2O as an inexpensive and efficient catalyst, some important bioactive β-hydroxyamides were obtained in moderate to excellent yields. The developed method features a wide substrate scope and good functional group tolerance. In addition, anticholinergic tropicamide was easily synthesized in this way.

Graphical abstract: Cobalt-catalyzed direct α-hydroxymethylation of amides with methanol as a C1 source

Supplementary files

Article information

Article type
Communication
Submitted
18 Nov 2021
Accepted
23 Dec 2021
First published
23 Dec 2021

Chem. Commun., 2022,58, 1382-1385

Cobalt-catalyzed direct α-hydroxymethylation of amides with methanol as a C1 source

B. Ma, R. Sun and J. Yang, Chem. Commun., 2022, 58, 1382 DOI: 10.1039/D1CC06501G

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