Issue 7, 2023
From the journal:

Chemical Communications

Bioengineering of BRAF and COX2 inhibitor nanogels to boost the immunotherapy of melanoma via pyroptosis†

Meng-Jie Zhang,‡a   Meng-Yun Liang,‡b   Shao-Chen Yang,a   Xian-Bin Ma,b   Shu-Cheng Wan,a   Qi-Chao Yang,a   Shuo Wang,a   Zhigang Xu ORCID logo *b  and  Zhi-Jun Sun ORCID logo *a  

* Corresponding authors

a The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, P. R. China
E-mail: sunzj@whu.edu.cn

b School of Materials and Energy & Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing 400715, P. R. China
E-mail: zgxu@swu.edu.cn

Abstract

Glutathione-responsive nanogels (CDNPs) crosslinked via crosslinker DBHD with the BRAF inhibitor dabrafenib and the COX2 inhibitor celecoxib were fabricated. The CDNPs can effectively induce tumor cell pyroptosis to activate robust antitumor immunity. Additionally, CDNPs combined with αPD-1 antibody greatly inhibited tumor growth in a melanoma mouse model with a prolonged survival time.

Graphical abstract: Bioengineering of BRAF and COX2 inhibitor nanogels to boost the immunotherapy of melanoma via pyroptosis

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Article information

DOI
https://doi.org/10.1039/D2CC05498A
Article type
Communication
Submitted
12 Oct 2022
Accepted
12 Dec 2022
First published
04 Jan 2023

Chem. Commun., 2023,59, 932-935

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Bioengineering of BRAF and COX2 inhibitor nanogels to boost the immunotherapy of melanoma via pyroptosis

M. Zhang, M. Liang, S. Yang, X. Ma, S. Wan, Q. Yang, S. Wang, Z. Xu and Z. Sun, Chem. Commun., 2023, 59, 932 DOI: 10.1039/D2CC05498A

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