NAD(P)H: quinone oxidoreductase 1 activatable toll-like receptor 7/8 agonist designed for precise immunotherapy

Guo Li; Yongxiao Xu; Xiaojie Kong; Liuwei Gu; Yuling Qin; Li Wu

doi:10.1039/D3CC00663H

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NAD(P)H: quinone oxidoreductase 1 activatable toll-like receptor 7/8 agonist designed for precise immunotherapy†

Guo Li,‡^a Yongxiao Xu,‡^a Xiaojie Kong,^a Liuwei Gu,^a Yuling Qin

*^a and Li Wu

*^a

Author affiliations

* Corresponding authors

^a Nantong Key Laboratory of Public Health and Medical Analysis, School of Public Health, Nantong University, No. 9, Seyuan Road, Nantong 226019, Jiangsu, P. R. China
E-mail: ylqin@ntu.edu.cn, wuli8686@ntu.edu.cn

Abstract

An NQO1-responsive precursor, named R848-QPA, has been developed to evoke an anti-tumor immune response. R848-QPA can induce innate immune activation when activated by overexpressed NQO1 in the tumor microenvironment while showing lower activity in NQO1-deprived environments. This strategy provides a new method for the development of tumor-microenvironment-responsive prodrugs for antitumor immunotherapy.

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Article information

DOI: https://doi.org/10.1039/D3CC00663H
Article type: Communication
Submitted: 13 Feb 2023
Accepted: 26 Apr 2023
First published: 27 Apr 2023

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Chem. Commun., 2023,59, 6343-6346

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NAD(P)H: quinone oxidoreductase 1 activatable toll-like receptor 7/8 agonist designed for precise immunotherapy

G. Li, Y. Xu, X. Kong, L. Gu, Y. Qin and L. Wu, Chem. Commun., 2023, 59, 6343 DOI: 10.1039/D3CC00663H

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Chemical Communications

NAD(P)H: quinone oxidoreductase 1 activatable toll-like receptor 7/8 agonist designed for precise immunotherapy†

Abstract

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NAD(P)H: quinone oxidoreductase 1 activatable toll-like receptor 7/8 agonist designed for precise immunotherapy

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