Aqueous mediated iodine catalyzed C–N coupling followed by C–C coupling towards 5H-pyrazino[2,3-b]indoles

Abstract

Our study describes a new development featuring iodine-catalyzed two consecutive oxidative cross-coupling reactions involving C_α(sp³)–H of benzyl amines followed by intramolecular cyclization in water under air. Here, C–N coupling followed by C–C coupling occurs in a green environment to provide a variety of 5H-pyrazino[2,3-b]indoles within a short time period.