Issue 6, 2023

Synthesis of tryptanthrin appended dispiropyrrolidine oxindoles and their antibacterial evaluation

Abstract

The synthesis of sixteen tryptanthrin appended dispiropyrrolidine oxindoles, employing [3 + 2] cycloaddition of tryptanthrin-derived azomethine ylides with isatilidenes, and their detailed antibacterial evaluation is described. The in vitro antibacterial activities of the compounds were evaluated against ESKAPE pathogens and clinically relevant drug-resistant MRSA/VRSA strains, from which the bromo-substituted dispiropyrrolidine oxindole 5b (MIC = 0.125 μg mL−1) was found to be a potent molecule against S. aureus ATCC 29213 with a good selectivity index.

Graphical abstract: Synthesis of tryptanthrin appended dispiropyrrolidine oxindoles and their antibacterial evaluation

Supplementary files

Article information

Article type
Research Article
Submitted
13 Jan 2023
Accepted
01 May 2023
First published
03 May 2023

RSC Med. Chem., 2023,14, 1165-1171

Synthesis of tryptanthrin appended dispiropyrrolidine oxindoles and their antibacterial evaluation

S. S. Leena, A. Akhir, D. Saxena, R. Maitra, S. Chopra and A. Deepthi, RSC Med. Chem., 2023, 14, 1165 DOI: 10.1039/D3MD00017F

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