Issue 6, 2023

Novel pirfenidone derivatives: synthesis and biological evaluation

Abstract

In order to discover novel anti-pulmonary fibrosis agents, a series of novel pirfenidone derivatives were designed and synthesized. All compounds were investigated for their anti-pulmonary activity and characterized by 13C and 1H nuclear magnetic resonance and high-resolution mass spectrometry. Preliminary studies on their biological activity showed that all target compounds showed different degrees of inhibition on pulmonary fibrosis, and most of the derivatives were significantly better than pirfenidone.

Graphical abstract: Novel pirfenidone derivatives: synthesis and biological evaluation

Supplementary files

Article information

Article type
Research Article
Submitted
16 Feb 2023
Accepted
25 Apr 2023
First published
19 May 2023

RSC Med. Chem., 2023,14, 1158-1164

Novel pirfenidone derivatives: synthesis and biological evaluation

M. Yao, M. Sun, C. Chen, L. Jin, H. Yang, Y. Li and S. Yin, RSC Med. Chem., 2023, 14, 1158 DOI: 10.1039/D3MD00072A

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