Twenty oxygenated aristolochene congeners were rapidly synthesised by combining genes from four different fungal pathways in the fungal host organism Aspergillus oryzae. Compounds produced in a single step include the natural product hypoxylan A and an epimer of guignaderemophilane C. A new fungal aromatase was discovered that produces phenols by oxidative demethylation.
Y. Sun, J. Gerke, K. Becker, E. Kuhnert, B. Verwaaijen, D. Wibberg, J. Kalinowski, M. Stadler and R. J. Cox, Chem. Sci., 2023, 14, 13463 DOI: 10.1039/D3SC04172G
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