Issue 10, 2024

Nickel-catalyzed oxidative thiolation of α-amino carbonyl compounds with thiols

Abstract

An efficient oxidative thiolation of α-amino carbonyl compounds with thiols by the catalysis of an Earth-abundant nickel salt is disclosed for the first time. A variety of alkyl thiols and (hetero)aryl thiols underwent the reaction well with α-amino ketones and an α-amino ester to produce the desired α,α-aminothiocarbonyl compounds in good to excellent yields under ligand- and base-free conditions.

Graphical abstract: Nickel-catalyzed oxidative thiolation of α-amino carbonyl compounds with thiols

Supplementary files

Article information

Article type
Communication
Submitted
08 Nov 2023
Accepted
09 Feb 2024
First published
13 Feb 2024

Org. Biomol. Chem., 2024,22, 2003-2006

Nickel-catalyzed oxidative thiolation of α-amino carbonyl compounds with thiols

G. Li, X. Zhao, J. Zhang, X. Liu, B. Sun and F. Xu, Org. Biomol. Chem., 2024, 22, 2003 DOI: 10.1039/D3OB01825C

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