Issue 10, 2024

A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces

Abstract

Surface-adhered bacteria on implants represent a major challenge for antibiotic treatment. We introduce hydrogel-coated surfaces loaded with tailored Pd-nanosheets which catalyze the release of antibiotics from inactive prodrugs. Masked and antibiotically inactive fluoroquinolone analogs were efficiently activated at the surface and prevented the formation of Staphylococcus aureus biofilms.

Graphical abstract: A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces

Supplementary files

Article information

Article type
Communication
Submitted
04 Jan 2024
Accepted
06 Feb 2024
First published
07 Feb 2024
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2024,22, 1998-2002

A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces

J. Braun, M. C. Ortega-Liebana, A. Unciti-Broceta and S. A. Sieber, Org. Biomol. Chem., 2024, 22, 1998 DOI: 10.1039/D4OB00014E

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