Issue 43, 2024

Effect of Polygonatum sibiricum on biological toxicity of zinc oxide nanoparticles during respiratory exposure

Abstract

Although zinc oxide nanoparticles (ZnO NPs) with distinct physicochemical properties have attracted great attention, the application of ZnO NPs is still limited due to their potential biotoxicity. In this work, ZnO-Polygonatum sibiricum (PS) NPs are synthesized to overcome this challenge. The ZnO NPs stably combine with PS according to microstructural observation, particle size distribution, zeta potential results and Fourier transform infrared spectroscopy analysis. The cytotoxicity of ZnO NPs is alleviated by combining them with PS as a consequence of the diminished generation of reactive oxygen species and reinforced superoxide dismutase activity. Furthermore, the respiratory index and histopathologic results of mice exposed to NPs manifest that the pulmonary dysfunction caused by ZnO NPs is avoided in the ZnO-PS NPs group. This study provides the foundations for the amelioration and universal utilization of ZnO NPs and emphasizes the potential of ZnO-PS NPs in biomedical applications.

Graphical abstract: Effect of Polygonatum sibiricum on biological toxicity of zinc oxide nanoparticles during respiratory exposure

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Article information

Article type
Paper
Submitted
21 May 2024
Accepted
30 Aug 2024
First published
02 Oct 2024
This article is Open Access
Creative Commons BY license

RSC Adv., 2024,14, 31360-31366

Effect of Polygonatum sibiricum on biological toxicity of zinc oxide nanoparticles during respiratory exposure

J. Yao, W. Yang, L. Tang, D. Yang, Y. Xu, S. Zhu and J. Zhu, RSC Adv., 2024, 14, 31360 DOI: 10.1039/D4RA03738C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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