Issue 43, 2024

Modified Cinnabaris-stabilized Pickering emulsions loaded with the essential oil of Acorus tatarinowii Schott: preparation, characterization and in vitro evaluation

Abstract

Essential oil of Acorus tatarinowii Schott (ATEO) have significant biological activity, but their physical and chemical properties are unstable and susceptible to interference by external factors, resulting in oxidation, decomposition, and isomerization of essential oils (EOs), ultimately diminishing the quality of EOs and escalating clinical risks. In this research, based on the concept of “ combination of medicine and adjuvant, ” the unsuitable stabilizer Cinnabaris in Lingzhu powder prescription was modified with a SiO2 surface to become a stabilizer suitable for Pickering emulsion. The modified Cinnabaris was synthesized, with a focus on exploring the surface modification of Cinnabaris to facilitate its role as a stabilizer in Pickering emulsion. Thermal stability studies showed that modified Cinnabaris-stabilized emulsion had higher EOs retention and lower peroxide value and hydrogen peroxide content. GC-MS analysis showed that the volatile components in the emulsion were more stable than the EOs. In vitro dissolution experiments showed that in the dissolution medium of artificial gastric juice and artificial intestinal juice, compared with the ATEO, the release in Pickering emulsion was faster within 48 h, indicating that the ATEO had been encapsulated in Pickering emulsion, which could improve the in vitro dissolution rate of EOs. This study convincingly demonstrates the potential of modified Cinnabaris-stabilized Pickering emulsion to improve the thermal stability and in vitro dissolution rate of EOs.

Graphical abstract: Modified Cinnabaris-stabilized Pickering emulsions loaded with the essential oil of Acorus tatarinowii Schott: preparation, characterization and in vitro evaluation

Supplementary files

Article information

Article type
Paper
Submitted
17 Jul 2024
Accepted
10 Sep 2024
First published
02 Oct 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 31367-31384

Modified Cinnabaris-stabilized Pickering emulsions loaded with the essential oil of Acorus tatarinowii Schott: preparation, characterization and in vitro evaluation

H. Ru, F. Luan, Y. Shi, X. Zhang, D. Guo, B. Zhai, J. Sun, D. Zhang, L. Feng and J. Zou, RSC Adv., 2024, 14, 31367 DOI: 10.1039/D4RA05168H

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