Issue 6, 2025, Issue in Progress
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RSC Advances

One-pot acid-catalysed synthesis of bis(1-imidazo[1,5-a]pyridyl)arylmethanes and evaluation of cytotoxic activities†

Tran Quang Hung, ORCID logo *a   Ban Van Phuc,a   Ha Nam Do,b   Thu Hue Tran,b   Hai Yen Nguyen,b   Nguyen Truong Phuoc,c   Truong Mai Chi,c   Dang Van Do,b   Truong T. T. Nga,a   Hien Nguyen,d   Van Tuyen Nguyen ORCID logo a  and  Tuan Thanh Dang ORCID logo *b  

* Corresponding authors

a Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Hanoi, Vietnam
E-mail: tqhung@ich.vast.vn

b Faculty of Chemistry, VNU-Hanoi University of Science, 19 Le Thanh Tong, Hanoi, Vietnam
E-mail: dangthanhtuan@hus.edu.vn

c Hanoi-Amsterdam High School for Gifted, Hoang Minh Giam, Cau Giay, Hanoi, Vietnam

d Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy, Hanoi, Vietnam

Abstract

A practical and efficient approach for the acid-catalysed synthesis of bis(1-imidazo[1,5-a]pyridyl)arylmethane (BimPy) derivatives has been described. Interestingly, these BimPys showed potential cytotoxicity against various cancer cell lines (SK-LU-1, MCF-7, HepG2).

Graphical abstract: One-pot acid-catalysed synthesis of bis(1-imidazo[1,5-a]pyridyl)arylmethanes and evaluation of cytotoxic activities

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Article information

DOI
https://doi.org/10.1039/D4RA08868A
Article type
Paper
Submitted
18 Dec 2024
Accepted
15 Jan 2025
First published
10 Feb 2025
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2025,15, 4274-4280

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One-pot acid-catalysed synthesis of bis(1-imidazo[1,5-a]pyridyl)arylmethanes and evaluation of cytotoxic activities

T. Q. Hung, B. V. Phuc, H. N. Do, T. H. Tran, H. Y. Nguyen, N. Truong Phuoc, T. M. Chi, D. V. Do, T. T. T. Nga, H. Nguyen, V. T. Nguyen and T. T. Dang, RSC Adv., 2025, 15, 4274 DOI: 10.1039/D4RA08868A

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