Issue 89, 2012

Effects of fullerene derivatives on bioluminescence and application for protease detection

Abstract

The effects of two C60 derivatives: C60[C(COOH)2]3 and C60(NH2)x(OH)y, have been investigated on the bioluminescence of humanized Gaussia luciferase (hGluc) for the first time. Utilizing the dual properties of carboxyl C60 with luminescence quenching and free radicals scavenging, a novel BRET system was constructed for protease detection with high sensitivity.

Graphical abstract: Effects of fullerene derivatives on bioluminescence and application for protease detection

Supplementary files

Article information

Article type
Communication
Submitted
22 Jul 2012
Accepted
19 Sep 2012
First published
21 Sep 2012

Chem. Commun., 2012,48, 11011-11013

Effects of fullerene derivatives on bioluminescence and application for protease detection

J. Yu, M. Guan, F. Li, Z. Zhang, C. Wang, C. Shu, H. Wei and X. Zhang, Chem. Commun., 2012, 48, 11011 DOI: 10.1039/C2CC36099C

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