Issue 77, 2013
From the journal:

Chemical Communications

Thiolated 2-methacryloyloxyethyl phosphorylcholine for an antifouling biosensor platform†

Tatsuro Goda,*a   Miyuki Tabata,a   Mai Sanjoh,a   Mai Uchimura,b   Yasuhiko Iwasaki*b  and  Yuji Miyahara*a  

* Corresponding authors

a Institute of Biomaterial and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan
E-mail: goda.bsr@tmd.ac.jp, miyahara.bsr@tmd.ac.jp

b Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan
E-mail: yasu.bmt@kansai-u.ac.jp

Abstract

We developed a new building block for a protein- and cell-repellant self-assembled monolayer (SAM) from 2-methacryloyloxyethyl phosphorylcholine (MPC) via a simple Michael-type addition to one mercapto group in alkanedithiol. The thiolated MPC can enable functionalization of a noble metal electrode to minimize noise signal in biosensing.

Graphical abstract: Thiolated 2-methacryloyloxyethyl phosphorylcholine for an antifouling biosensor platform

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Article information

DOI
https://doi.org/10.1039/C3CC44357D
Article type
Communication
Submitted
10 Jun 2013
Accepted
31 Jul 2013
First published
31 Jul 2013

Chem. Commun., 2013,49, 8683-8685

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Thiolated 2-methacryloyloxyethyl phosphorylcholine for an antifouling biosensor platform

T. Goda, M. Tabata, M. Sanjoh, M. Uchimura, Y. Iwasaki and Y. Miyahara, Chem. Commun., 2013, 49, 8683 DOI: 10.1039/C3CC44357D

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