Mingliang Wang, Xixi Liu, Lu Zhou, Jidong Zhu and Xun Sun
Org. Biomol. Chem., 2015,13, 3190-3193
DOI:
10.1039/C4OB02691H,
Communication
An efficient protocol was developed to access 3-fluoro-2-hydroxy-2-substituted benzo[b]furans with Selectfluor™ as the fluorinating reagent in MeCN and water. By utilizing SOCl2/Py as the dehydrating agent, the compounds above were readily converted to 3-fluorinated, 2-substituted benzo[b]furans in high yields.
![Graphical abstract: Fluorination of 2-substituted benzo[b]furans with Selectfluor™](/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C4OB02691H "Graphical abstract")
