Xin
Cui
,
Xue
Xu
,
Li-Mei
Jin
,
Lukasz
Wojtas
and
X. Peter
Zhang
*
Department of Chemistry, University of South Florida Tampa, FL 33620-5250, USA. E-mail: xpzhang@usf.edu; Fax: +1 813-974-1733; Tel: +1 813-974-7249
First published on 12th November 2014
Co(II)-based metalloradical catalysis has, for the first time, been successfully applied for asymmetric intramolecular C–H alkylation of acceptor/acceptor-substituted diazo reagents. Through the design and synthesis of a new D2-symmetric chiral amidoporphyrin as the supporting ligand, the Co(II)-based metalloradical system, which operates at room temperature, is capable of 1,5-C–H alkylation of α-methoxycarbonyl-α-diazosulfones with a broad range of electronic properties, providing the 5-membered sulfolane derivatives in high yields with excellent diastereoselectivities and enantioselectivities. In addition to complete chemoselectivity toward allylic and allenic C–H bonds, the Co(II)-based metalloradical catalysis for asymmetric C–H alkylation features a remarkable degree of functional group tolerance.
Scheme 1 C–H functionalization by a) electrophilic metallocarbene insertion and b) radical C–H alkylation via MRC. |
Among previous efforts toward enantioselective C–H alkylation with A/A-substituted diazo reagents,7 the most notable example is the Cu-based intramolecular system recently reported by Maguire and coworkers.8 Supported by chiral bisoxazoline ligands, this Cu-catalyzed asymmetric system was shown to enable intramolecular C–H insertion with α-alkoxycarbonyl-α-diazosulfones, affording the corresponding six-membered thiopyrans in high enantioselectivities.8 However, the yields of the desired products were generally low to moderate (30–68%) as the Cu-catalyzed reactions typically gave a complex mixture of products. Furthermore, it was reported that the efficiency of the catalytic system was further reduced for C–H substrates with decreased electron richness. For example, the insertion reaction was completely inhibited for benzylic C–H bonds with an electron-withdrawing NO2 group substituted at the para-position of the phenyl ring.8a Evidently, general and effective catalytic systems for asymmetric C–H alkylation via metal-mediated carbene insertion with A/A-substituted diazo reagents remain to be developed, despite extensive efforts undertaken.2f Besides seeking further improvements on existing catalytic systems, exploration of fundamentally different pathways involving intermediates other than Fischer-type electrophilic metallocarbenes may provide new opportunities for addressing this and related challenges in asymmetric C–H alkylation.
As stable low-spin 15e-metalloradicals, cobalt(II) porphyrin complexes, [Co(Por)], have been disclosed to activate diazo reagents to form α-Co(III)-alkyl radicals (also known as Co(III)-carbene radicals), which serve as key intermediates in Co(II)-based metalloradical catalysis (MRC).9 Unlike the electrophilic Fischer-type carbene intermediates, α-Co(III)-alkyl radicals have been demonstrated to undergo radical addition to alkenes and alkynes, followed by radical cyclization, leading to the development of catalytic radical cyclopropanation,3e,10 cyclopropenation11 and furanylation reactions.12 Considering the genuine radical nature of the metalloalkyl radical intermediates, we envisioned the possibility of a new C–H alkylation process (Scheme 1b) if (i) the α-Co(III)-alkyl radical is capable of abstracting a C–H bond hydrogen atom and (ii) the subsequent radical substitution reaction between the resulting alkyl radical and Co(III)-alkyl complex could proceed effectively. This type of metalloradical alkylation would be both fundamentally interesting and practically attractive as the radical pathway would be much less dependent on the electronic properties of the diazo reagents and C–H substrates, potentially leading to the development of a general catalytic system for C–H alkylation, including with A/A-substituted diazo reagents and for electron-deficient C–H bonds. Moreover, as another notable feature of radical reactions, this type of C–H functionalization would be expected to have a high degree of functional group tolerance.13
As the outcome of our efforts toward the development of radical-type C–H alkylation, we report herein the first Co(II)-based metalloradical system that is highly effective for asymmetric intramolecular C–H alkylation with α-methoxycarbonyl-α-diazosulfones, a class of A/A-substituted diazo reagents. The new Co(II)-catalyzed system can proceed at room temperature and is capable of alkylating C–H bonds with wide-ranging electronic properties, including challenging electron-deficient C–H bonds. In addition to high diastereo- and enantioselectivity, the metalloradical process features a remarkable degree of tolerance toward various functionalities, including unprotected OH and NH2 groups, as well as excellent chemoselectivity for allylic/allenic C–H alkylation.
Entry | Catalyst (loading) | Yieldb (%) | drc | eed (%) |
---|---|---|---|---|
a Reactions were carried out at room temperature for 72 h in a one-time fashion without slow addition of the diazo reagent using [Co(Por)] under N2. b Isolated yields. c The trans:cis diastereomeric ratio determined by 1H-NMR. d Enantiomeric excess determined by chiral HPLC. e No reaction. f For clarity, the other two meso-groups of the porphyrin are omitted. | ||||
1 | [Co(TPP)] (120 mol%) | NRe | — | — |
2 | [Co(P1)] (2 mol%) | 83 | 95:5 | −24 |
3 | [Co(P2)] (2 mol%) | 63 | 96:4 | 91 |
4 | [Co(P3)] (2 mol%) | 92 | 96:4 | 92 |
The [Co(P3)]-catalyzed intramolecular C–H alkylation was demonstrated to be applicable to A/A-substituted diazo reagents, α-methoxycarbonyl-α-diazosulfones 1, containing different types of C–H bonds with varied electronic properties and substituents, leading to the stereoselective formation of trans-sulfolane derivatives 2 (Table 2). In addition to 1a bearing the electron-withdrawing NO2 group, diazo reagents 1b–f with various halogen substituents such as CF3, F, Cl, and Br could also be transformed by [Co(P3)] to the corresponding sulfolanes 2b–f in high yields with high stereoselectivities (entries 1–6). As expected, α-diazosulfones with electron-neutral aryl units such as non-substituted phenyl (1g) and para-methylphenyl groups (1h) were also suitable substrates for the Co(II)-based system, providing the desired C–H alkylation products 2g and 2h in similarly high yields and stereoselectivities (entries 7 and 8). The relative and absolute configurations of the two contiguous chiral centers in 2g were established as [2S,3R] by X-ray crystal structural analysis (see ESI†). Likewise, electron-rich benzylic C–H bonds could also be effectively alkylated by the Co(II)-based catalytic system, as demonstrated with the high-yielding and highly selective reactions of diazo reagents 1i and 1j containing electron-donating 4-alkoxyphenyl groups (entries 9 and 10). These results indicate that the Co(II)-catalyzed asymmetric alkylation is insensitive to the electronics of the C–H substrates, which is in line with the envisioned radical mechanism (Scheme 1b).
a Syntheses of catalysts and diazo compounds are summarized in ESI;15 reactions were carried out at room temperature for 72 h using [Co(P3)] under N2; isolated yields; the trans:cis diastereomeric ratios were determined by 1H-NMR; enantiomeric excesses were determined by chiral HPLC. b [2S,3R] absolute configuration determined by anomalous-dispersion effects in X-ray diffraction measurements on a crystal. c 5 mol% catalyst used. d PhF used as solvent. |
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The [Co(P3)]-based catalytic system was further shown to display other attractive features that are unique for radical processes. Firstly, the metalloradical C–H alkylation was found to tolerate well various functional groups. For example, C–H substrates containing unprotected hydroxyl (1k) and amino (1l) groups as well as amido (1m) and triazole (1n) functionalities could undergo catalytic intramolecular alkylation reactions without affecting these usually reactive functional groups, providing highly functionalized trans-sulfolanes 2k–n in excellent yields with high stereoselectivities (entries 11–14). Secondly, excellent chemoselectivity for intramolecular allylic C–H alkylation to form 5-membered sulfolanes versus CC cyclopropanation to form bicyclo[4.1.0] structures was observed for this Co(II)-based metalloradical catalysis. Allylic C–H substrates such as 1o and 1p were chemoselectively alkylated to form sulfolanes 2o and 2p exclusively (entries 15 and 16), without any complications from the competitive cyclopropanations of the neighboring CC bonds.16 Besides allylic C–H bonds, chemoselective alkylation of allenic C–H bonds could also be achieved by [Co(P3)], as exemplified with substrate 1q, affording the corresponding sulfolane 2q in an excellent yield without any side reactions (entry 17). The remarkable chemoselectivity as well as functional group tolerance, together with the observed electronic insensitivity, highlight the unique features of this Co(II)-based metalloradical alkylation system.17
The demonstrated reactivity and selectivity profile of the Co(II)-catalyzed C–H alkylation is in good agreement with the anticipated radical pathway of metalloradical catalysis (MRC) (Scheme 1b). To directly probe the radical mechanism, we investigated potential E–Z olefin isomerization of Co(II)-catalyzed allylic C–H alkylation. Different from the concerted insertion pathway (Scheme 1a), the radical allylic alkylation would involve formation of allylic radical intermediates as a result of H-atom abstraction of allylic C–H bonds by the initial α-Co(III)-alkyl radicals. In view of the facile E–Z interconversion of allylic radicals,10b,18 the catalytic reaction of isomerically pure allylic C–H substrates could lead to the formation of a mixture of (E)- and (Z)-alkylation products. To this end, α-methoxycarbonyl-α-diazosulfones 1r and 1s, which were derived from the (E)- and (Z)-isomers of 2-hexene, respectively, were employed as radical probe substrates for Co(II)-based metalloradical alkylation. As expected, E–Z isomerization was observed in the alkylation reactions of both 1r and 1s, producing isomeric mixtures of products 2r and 2s in high combined yields (Table 3). Interestingly, the degree of the isomerization could be controlled by Co(II) catalysts with different ligand environments. With use of the sterically encumbered [Co(P3)] catalyst, both 1r and 1s tended to mostly retain their olefin configuration with only slight isomerization observed (entries 1 and 4). When the less sterically hindered [Co(P4)] (P4 = 3,5-DitBu-IbuPhyrin) was used as the catalyst, an increase in the degree of isomerization was observed for both alkylation reactions (entries 2 and 5). These results indicate that the degree of isomerization of the allylic radicals is kinetically controlled by the ligand sterics. Accordingly, by using even less sterically hindered [Co(P5)] (P5 = meso-nBu-IbuPhyrin) as the catalyst, further increases in isomerization were observed in both reactions (entries 3 and 6). In fact, [Co(P5)]-catalyzed alkylation reactions of both 1r and 1s generated mixtures of 2r and 2s with similar ratios (entries 3 and 6), suggesting near equilibrium distributions of the two isomeric products. The results from these isomerization experiments provide further support of the proposed radical mechanism for the Co(II)-catalyzed alkylation.
The Co(II)-catalyzed asymmetric C–H alkylation allowed for stereoselective construction of 5-membered sulfolane structures with concurrent creation of two contiguous stereogenic centers. By taking advantage of the acidity of the chiral methine unit between the two electron-withdrawing groups, sulfolanes 2 could be further transformed to produce more densely functionalized derivatives 3 (Table 4), which may find interesting biomedical applications.19 For example, enantioenriched sulfolanes 2i and 2e could be selectively fluorinated with selectfluor after facile deprotonation of the acidic chiral center, affording compounds 3ia and 3ea, respectively, in high yields with excellent diastereoselectivities and without affecting the original enantiopurities (entries 1 and 2). The absolute configuration of the two contiguous stereocenters in 3ea, including the newly-created quaternary chiral center, was established as [2R,3R] by X-ray crystal structural analysis (see ESI†). Highly stereoselective chlorination and methylation could be similarly achieved as demonstrated with the high-yielding production of compounds 3ib (entry 3) and 3ic (entry 4), respectively, from 2i. Besides nucleophilic substitution reactions, the resulting carbanion from the acidic chiral center in 2 could also be employed for Michael addition as exemplified by the reaction of 2i with ethyl acrylate, affording multi-functional sulfolane 3id while retaining the original optical purity (entry 5).
Entry | Electrophile | Product | Yield (%) | dr | ee (%) |
---|---|---|---|---|---|
a Compound 2 was treated with 1.2 equiv. of NaH in THF at room temperature, followed by the addition of 1.1 equiv. of electrophile and the subsequent stirring of the reaction mixture for 12 h; isolated yields; the trans:cis diastereomeric ratios were determined by 1H-NMR; enantiomeric excesses were determined by chiral HPLC. b THF/DMF (2:1) used as solvent. c [2R,3R] absolute configuration determined by anomalous-dispersion effects in X-ray diffraction measurements on a crystal. d The reaction was stirred for 3 h. | |||||
1b | Selectfluor | 92 | 96:4 | 94 | |
2b | Selectfluor | 89 | 96:4 | 84 | |
3 | NCS | 92 | 97:3 | 93 | |
4 | MeI | 91 | 8:92 | 93 | |
5d | Ethyl acrylate | 60 | 4:96 | 93 |
Footnote |
† Electronic supplementary information (ESI) available. CCDC 1020629–1020631. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc02610a |
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