Henry T. W.
Shere
,
Han-Ying
Liu
,
Samuel E.
Neale
,
Michael S.
Hill
*,
Mary F.
Mahon
and
Claire L.
McMullin
*
Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK. E-mail: msh27@bath.ac.uk; cm2025@bath.ac.uk
First published on 30th April 2024
Reactions of β-diketiminato alkaline earth alkyldiboranate derivatives [(BDI)Ae{pinBB(R)pin}] (BDI = HC{(Me)CNDipp}2; Dipp = 2,6-i-Pr2C6H3; Ae = Mg, R = n-Bu or Ae = Ca, R = n-hexyl) with t-BuNC provide access to the respective group 2 derivatives of unprecedented diborata-allyl, {(pinB)2CNBpin(t-Bu)}−, anions. Although the necessary mode of B–C bond cleavage implicated in these transformations could not be elucidated, further studies of the reactivity of magnesium triboranates toward isonitriles delivered a more general and rational synthetic access to analogous anionic moieties. Extending this latter reactivity to a less symmetric triboranate variant also provided an isomeric Mg–C-bonded dibora-alkyl species and sufficient experimental insight to prompt theoretical evaluation of this reactivity. DFT calculations, thus, support a reaction pathway predicated on initial RNC attack at a peripheral boron centre and the intermediacy of such dibora-alkyl intermediates.
While the incorporation of planar (sp2) boron into the structures of aromatic heterocycles and polycyclic aromatic hydrocarbons (PAHs) continues as an area of recent topicality,16–20 similar modification of many fundamental organic moieties remains to be achieved. A case in point is trimethylenemethane (I), the D3h structure of which, though conjugated, represents a non-Kekulé hydrocarbon in that no resonance structure allows its four available electrons to be distributed across three C–C π bonds (Fig. 1).21–23 Analysis of the frontier molecular orbitals of I identifies its HOMO as two degenerate half-filled (e′′) π-symmetric wavefunctions, such that Hund's rule dictates its ground state as a triplet diradical.24,25 Frontier MO degeneracy is lost, however, by any lowering of molecular symmetry, either by Jahn–Teller distortion or hetero-replacement of one of its carbon atoms.26 The lower (C2v) symmetry of the iminiumdimethylenemethane cation (II), for example, in which a single methylene of I is substituted by (NH2)+ provides a now closed shell singlet species with a fully occupied (b1) HOMO. While II and related wholly organic species have attracted some experimental and theoretical scrutiny,25,27–29 boron-centred substitution of I has evaded consideration. Isolobal progression from II, for example, may be envisaged by sequential replacement of methylene by {BX2}− (where X represents any sigma-bonded heteroelement) to provide the respective hypothetical neutral and anionic analogues, III and IV.
Fig. 1 Isolobal progression from the triplet diradical ground state of (one resonance hybrid of) trimethylenemethane (I) to the hypothetical singlet species II, III and IV. |
The current work arises from our study of the β-diketiminato (BDI = HC{(Me)CNDipp}2; Dipp = 2,6-i-Pr2C6H3) magnesium and calcium alkyl diboranate derivatives, compounds 1 and 2 (Scheme 1),30,31 which are obtained by reaction of bis(pinacolato)diboron (B2pin2) with the relevant alkaline earth alkyls.32–35 In common with other systems resulting in a desymmetrization of B2pin2,36–38 compound 1 behaves as a surrogate source of the [Bpin]− anion enabling B–C bond formation when treated, for example, with t-BuCN (Scheme 1).39 Analysis of this reactivity by density functional theory (DFT) indicated that B–B′ heterolysis is induced by (‘inner sphere’) coordination at magnesium, rather than (‘outer sphere’) interaction with the trigonal boron of the diboranate anion.31 Although reaction of 2 with t-BuCN resulted in similar ‘inner sphere’ coordination to the group 2 centre, the resultant calcium nitrile adduct was stable to onward transformation, behaviour rationalised to result from the greater ability of the larger alkaline earth cation to support a 5-coordinate geometry and a consequent inability to displace RBpin (Scheme 1).31
Diverse insertion and bond activation reactivity has also been observed when either boron–boron or metal–boron bonded compounds are treated with isonitriles.40–49 In this contribution, therefore, we report that compounds 1 and 2 react with the isonitrile isomer of t-BuCN, t-BuNC, to provide an unusual diborata-allyl anion, which may also be considered as an isoelectronic (albeit non-isolobal) analogue of trimethylenemethane (see IV, Fig. 1). Although the initial identification of this reactivity was serendipitous, we further report that a more rational and general synthesis of such anions may be achieved by use of magnesium triboranate derivatives, a protocol which is also amenable to more confident theoretical (DFT) analysis.
Fractional crystallisation of both crude reaction mixtures from mixed toluene/n-hexane solvent systems allowed the separation of compounds 3 and 4, which were isolated in yields of 39 and 45% from the respective magnesium- and calcium-based reactions (Scheme 2). Analysis by 1H NMR spectroscopy of both crystalline samples now indicated the presence of single magnesium- (3, γ-methine δ 4.91 ppm) and calcium-bound (4, γ-methine δ 4.70 ppm) BDI ligand environments, while the 11B{1H} spectra displayed signals consistent with, in each case, the presence of two discriminated three-coordinate boron nuclei [3: δ 34.2, 25.2; 4: 34.3, 25.5 ppm].
The origin of these observations was resolved by single crystal X-ray diffraction analysis performed on both 3 and 4, the results of which are shown in Fig. 2 with selected bond lengths and angle data presented in Table 1. Although not isostructural, both compounds present connectivities that differ only in the identity of the group 2 metal centre. Any minor variations in the comparable metric data may, thus, be attributed to the differing radii of the alkaline earth cations.51 In both cases the pseudo-tetrahedral geometries of the BDI-chelated group 2 cations are completed by O,O-coordination of a borylamino-diborata-allyl anion. The central (C42) carbon atoms can be identified as arising from the terminal carbon of the t-BuNC reagent through their maintenance of the N3–C42 bonds, while N3 is further bound by a third [Bpin] moiety. The B–C42 bonds in both compounds [3: B1–C42 1.467(2), B2–C42 1.477(2); 4: B1–C42 1.4888(18), B2–C42 1.4786 Å] are significantly shorter than is typical for a B–C single bond to three-coordinate boron (ca. 1.58–1.62 Å).12 These distances, thus, lie within the range established for interactions which incorporate a significant degree of B–C π bonding such as in [Mes2BCH2]− (1.444(8) Å),12 8,10,11a-trimethyl-7-mesityl-11aH-7-boratabenzo[de]anthracene (1.48 Å)52 and various boratabenzene-type molecules.53,54 B1, C42 and B2 adopt trigonal planar geometries in both structures, with sums of angles subtended about C42 of 360°. While the {CB2} units also adopt coplanar orientations with respect to N3, the least squares planes defined by [N3–C42–B1–O1–Ae1–O3–B2] and [B3–N3–C43] are effectively orthogonal in both structures (3, Ae = Mg: 88.14; 4, Ae = Ca 88.08°). Although the N3 atoms are also trigonal, the absence of π conjugation of these centres with C42 is evident in the N3–C42 bond lengths (3: 1.4816(19); 4: 1.4815(15) Å], which are only marginally shorter than the bonds between N3 and their tert-butyl substituents [3: 1.498(2); 4: 1.4865(16) Å] and, thus, consistent with reduction of the isonitrile NC interaction [1.184 Å] to a single bond.55 Although the {NCB2} sigma frameworks of the complex anion cores are isoelectronic with the anionic skeleton of IV (Fig. 1), the forfeit of extended π-conjugation across all four atoms dictates that their description as complete dimethylenemethane isosteres would be incorrect. Rather, the still delocalised units are better rationalised as diborata-allyl anions, each bearing a pendent borylamino {N(t-Bu)(Bpin)} substituent.
3 | 4 | 7 | 8 | |
---|---|---|---|---|
a M1 = Mg. b M1 = Ca. c Mg1–O5. d Mg1–C36. e B1–C36. f B2–C36. g N3–C36. h O5–Mg1–C36. i B1–C42–B2. j B1–C36–N3. k B1–C36–N3. | ||||
M1–O1 | 2.0577(8) | 2.2927(9) | 2.0454(9) | 2.0642(11)c |
M1–O3 | 1.9811(8) | 2.2487(9) | 1.9700(9) | 2.2254(14)d |
M1–N1 | 2.0657(10) | 2.3153(11) | 2.0411(11) | 2.0654(13) |
M1–N2 | 2.0630(10) | 2.3125(10) | 2.0607(11) | 2.0894(12) |
B1–C42 | 1.4758(16) | 1.4888(18) | 1.4800(18) | 1.535(2)e |
B2–C42 | 1.4642(16) | 1.4786(18) | 1.4726(17) | 1.530(2)f |
N3–C42 | 1.4805(13) | 1.4815(15) | 1.4785(15) | 1.4966(17)g |
N3–B3 | 1.3934(16) | 1.3933(19) | 1.3988(17) | 1.394(2) |
O1–M1–O3 | 99.03(3) | 92.04(3) | 97.82(4) | 80.87(5)h |
N1–M1–N2 | 93.52(4) | 84.13(4) | 93.87(4) | 93.13(5) |
B1–C42–B2 | 127.25(10) | 130.84(12) | 126.84(11) | 114.12(12)i |
B1–C42–N3 | 116.55(9) | 113.10(11) | 115.40(10) | 115.26(12)j |
B2–C42–N3 | 116.15(9) | 115.46(10) | 117.63(10) | 118.89(12)k |
This interpretation of the bonding within the borylamino-diborata-allyl moieties of compounds 3 and 4 was validated by MO analysis of both compound 3 and the non-complexed anion itself. In both cases, the HOMO was identified as a molecular orbital comprising delocalised B–C–B π-bonding (Fig. 3 and S25†), with Wiberg Bond Indices (WBIs) of ca. 1.2 for each B–C bond and 0.94 for the N–C interaction across the {NCB2} core of the anion.
Fig. 3 HOMO of the borylamino-diborata-allyl anion, which predominantly features B–C–B π-bonding character, computed at the BP86-D3BJ/6-311++G**//BP86/BS1 level of theory. |
As discussed above, inspection of the initial 1H and 11B{1H} NMR spectra of both reactions leading to the isolation of 3 and 4 evidenced the formation of additional products. Although no definitive identification of any other compounds could be achieved, we tentatively suggest that the concurrent generation of alkaline earth dialkylborate, [R2Bpin]−, species provides a plausible rationalisation of the reaction mass balance and, specifically, the 4-coordinate boron environments apparent in the initially recorded 11B{1H} NMR spectra. The characterisation of compounds 3 and 4 and isolated yields approaching 50% are also suggestive of reactions that approximate to a supposed 1:1 stoichiometry with such dialkylborate co-products. Although we decline to assign a compound number to these proposed species, previous observations of similar dismutation of HBpin to [H2Bpin]− in a number of magnesium-56–60 and calcium-based61 systems provides tentative support for this hypothesis.
Scheme 3 (a) Synthesis of compounds 3 and 7via compound 5; (b) synthesis of compound 8via compound 6. |
Accordingly, a reaction was performed between compound 5 and t-BuNC (Scheme 3a). This procedure provided a single solution species that presented 1H, 13C{1H} and 11B{1H} NMR spectra identical to those of a pure sample of compound 3. Furthermore, crystallisation from the reaction solution enabled the isolation of a high (>70%) yield of compound 3, the formation of which was further corroborated by a unit cell check performed on a single crystal.
With this rational route to compound 3 in hand, the generality of this transformation was assessed by treatment of compound 5 with cyclohexyl isonitrile (Scheme 3a). This procedure yielded selective conversion to a single β-diketiminato product, compound 7, which presented NMR spectra suggestive of a solution symmetry strongly reminiscent of that of compound 3. The supposed generation of a N-cyclohexyl substituted variant of the borylamino-diborata-allyl anion was confirmed by the isolation of compound 7 as colourless single crystals (66%) and subsequent X-ray diffraction analysis.
Although the close comparison of the solid-state structure of 7 (Fig. 4a and Table 1) to that of compound 3 obviates further comment, the selective transformation of compound 5 and its delivery of three equivalents of the {Bpin} unit to both compounds 3 and 7 prompts consideration of a number of mechanistic possibilities. We have previously suggested that B–B′ heterolysis in molecules such as 1 and 2 may be induced either by (‘inner sphere’) interaction of a basic substrate molecule with the alkali metal centre itself or (‘outer sphere’) approach to the 3-coordinate boron atom of the {pinBB(R)pin}− anion.30,62–65 While we have previously observed some structural evidence for these contrasting possibilities, in the current context, the identical constitution of all three {Bpin} components of the triboranate anion of 5 does not allow regiochemical discrimination of their delivery to the isonitrile NC bond. We have, however, also previously reported that reaction of compound 1 with the alternative diborane(4) ester, 5,5,5′,5′-tetramethyl-2,2′-bi(1,3,2-dioxaborinane) (B2neo2) provides compound 6 through selective formation of the similarly homocatenated but now asymmetrically-borylated {(Bneo)B(neo)(Bpin)}− anion (Scheme 3b).
Reasoning this latter moiety would provide a means for discrimination between the reactivity of the {Bneo} and {Bpin} components, compound 6 was treated with an equimolar quantity of t-BuNC. Although the complexity of the 1H NMR spectrum provided by the resultant orange solution provided only limited insight into the outcome of the reaction, it was clearly evident that a single new β-diketiminato magnesium species (8; BDI γ-methine δH 4.82 ppm) had been formed (Scheme 3b). Single crystals of compound 8 were obtained by slow evaporation of the benzene reaction solution and its identification was achieved by X-ray diffraction analysis (Fig. 4b and Table 1).
The three boron ester functions of compound 6 again result in the generation of two B–C bonds and a single B–N bond such that the isonitrile-derived moiety is constitutionally analogous to those observed in all three compounds, 3, 4 and 7. The newly formed anion of compound 8, however, adopts a contrasting configuration and a different mode of coordination to the alkaline earth centre. While still bidentate, engagement with Mg1 is now achieved through coordination by the tetravalent C36 atom and O5, a constituent of a nitrogen-bound {Bneo} moiety. Although the Mg1–C36 bond length [2.2254(14) Å] is elongated in comparison to typical Mg–Calkyl interactions in which magnesium is similarly 4-coordinate (ca. 2.14–2.15 Å), the pyramidalisation at C36 indicates that compound 8 is better considered as a σ-bonded organometallic derivative. This latter inference is also supported by the C36–B1 [1.535(2) Å] and C36–B2 [1.530(2) Å] bonds, both of which are significantly longer than the analogous C42–B1/2 interactions (ca. 1.47 Å) observed in compounds 3, 4 and 7 (Table 1). While this observation is consistent with the loss of π-conjugation attributed to these latter bonds, of more general significance is the dissimilar identity of the two C-bonded boron ester units of 8, which have resulted from the installation of the unique {Bpin} and a single {Bneo} component of the {(Bneo)B(neo)(Bpin)}− anion of 5. Any mechanistic hypothesis must, therefore, account for the notable regioselectivity of this outcome.
DFT calculations were employed (BP86-D3,PCM = toluene/BS2//BP86/BS1 level) to interrogate the mechanism of formation of diborata-allylmagnesium adduct PM (3) through addition of t-BuNC to triboratomagnesium species I (Fig. 5). The steric demands of the triboranate anion of I ensure that initial interaction with the bulky isonitrile, t-BuNC, takes place via coordination to the outermost {Bpin} in the catenated triboron [B3pin3]− group, viaTS(I-II) (+14.1 kcal mol−1) to form II (+11.7 kcal mol−1). Subsequent B–B cleavage, by what is now effective carbene insertion, takes place viaTS(II-III) (+13.0 kcal mol−1) to form a 1,1-dipinacolboratoimine species, III. Onwards torsion rotation of the imine group about the B–C bond to form IV,66 precedes a rate-limiting B–N coupling process via a four-membered B–B–N–C geometry (TS(IV-V), −1.2 kcal mol−1). This transition state structure, with an energetic span of +19.9 kcal mol−1 relative to IV, invokes concomitant B–B bond cleavage whilst forming V (−56.8 kcal mol−1), in a process akin to σ-bond metathesis. Finally, a conformational rearrangement takes place via a modest barrier (13.2 kcal mol−1) at TS(V–P) (−43.6 kcal mol−1) to afford the observed borylamino-diborata-allyl species PM at −61.9 kcal mol−1.67 The structure of compound 8 presents a notable analogy with the computed Mg–C σ-bonded organomagnesium species, VP, which is formed en route to PM. We, thus, hypothesise that both triboranatomagnesium species undergo similar isonitrile addition mechanisms, whereby the divergence in the ultimate regiochemistry is governed by the thermodynamic favourability of the final structures. To this end, calculation of “Vneo” (ΔG = 0.0 kcal mol−1) (8) and its analogous but hypothetical borylamino-diborata-allyl isomer “Pneo” (ΔG = +8.6 kcal mol−1) from 6, revealed a computed thermodynamic preference for the pyramidal arrangement in the former species (Fig. 5, inset). This deduction is congruent with experimental observation and supports the hypothesis that the regiodivergent outcomes of the reactions of t-BuNC with either 1 or 6 arise from thermodynamic control in the latter stages of the isonitrile addition mechanism.
Footnote |
† Electronic supplementary information (ESI) available. Crystallographic data for all compounds have been deposited with the Cambridge Crystallographic Data Centre as supplementary publications CCDC 2298656, 2298657, 2341389 and 2341390 for 3, 4, 7 and 8, respectively. For ESI and crystallographic data in CIF or other electronic format see DOI: https://doi.org/10.1039/d4sc01953a |
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