Issue 9, 2025
From the journal:

Chemical Communications

A biocompatible Ni(ii) complex as an amyloid sensor for human PrP106–126 fibrillar aggregates†‡

Rajat Saini, ORCID logo a   Rahul Chauhan,a   Sain Singh, ORCID logo a   Saakshi Saini,b   Govinda R. Navale, ORCID logo a   Abhishek Panwar,c   Prashant Kukreti,a   Imtiaz Ahmed,a   Partha Roy ORCID logo b  and  Kaushik Ghosh ORCID logo *ab  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology, Roorkee 247667, India
E-mail: kaushik.ghosh@cy.iitr.ac.in

b Department of Biosciences and Bioengineering, Indian Institute of Technology, Roorkee 247667, India
E-mail: kg@bt.iitr.ac.in

c Department of Chemistry, National Institute of Technology Manipur, Langol-795004, India

Abstract

KRS-1, a biocompatible nickel(II) complex, is introduced as a potent fluorescent probe for PrP106–126 fibrillar aggregates. KRS-1 shows a 15-fold enhancement in PL intensity and detects all stages of PrP106–126 aggregation. Fluorescence microscopy confirms its efficacy in identifying PrP106–126 fibrillar aggregates in HT-22 cells.

Graphical abstract: A biocompatible Ni(ii) complex as an amyloid sensor for human PrP106–126 fibrillar aggregates

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Article information

DOI
https://doi.org/10.1039/D4CC04335A
Article type
Communication
Submitted
24 Aug 2024
Accepted
19 Dec 2024
First published
23 Dec 2024

Chem. Commun., 2025,61, 1862-1865

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A biocompatible Ni(II) complex as an amyloid sensor for human PrP106–126 fibrillar aggregates

R. Saini, R. Chauhan, S. Singh, S. Saini, G. R. Navale, A. Panwar, P. Kukreti, I. Ahmed, P. Roy and K. Ghosh, Chem. Commun., 2025, 61, 1862 DOI: 10.1039/D4CC04335A

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