Both gaseous N2O3 and N2O4, but not NO, are shown to effect the nitrosation of primary and secondary amines in neutral and alkaline aqueous solutions; the reaction rates are rapid, insensitive to amine basicity and are not inhibited by HO–, which is consistent with radical pathways involving NO2 and NO, and therefore carcinogenic N-nitrosamines may form under a much wider range of experimental conditions than hitherto suspected.
B. C. Challis and S. A. Kyrtopoulos, J. Chem. Soc., Chem. Commun., 1976, 877 DOI: 10.1039/C39760000877
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