L-Ascorbic acid has been synthesized via the regio- and stereo-selective reduction of D-threo-2,5-hexodiulosonic acid; this procedure also can be used for preparation of the 5-deuterio-compound.
G. Andrews, B. Bacon, T. Crawford and R. Breitenbach, J. Chem. Soc., Chem. Commun., 1979, 740 DOI: 10.1039/C39790000740
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