Chemical conversion of uridine into 4-thiouridine via the 4-(1,2,4-triazol-1-yl)pyrimidin-2(1H)-one intermediate

Abstract

In an aqueous solution of sodium hydrosulphide at room temperature, 4-(1,2,4-triazol-1-yl)-1-(2′,3′,5′-tri-O-acetyl-β-D-ribofuranosyl)pyrimidin-2(1H)-one, prepared from uridine, is converted into the 4-thiopyrimidin-2(1H)-one derivative which can be deacetylated to yield 4-thiouridine.