Linkage of a macrocyclic complexing agent to a spaced tri-maleimide allows formation of a recombinant trivalent antibody by reaction with a Δ-Cys Fab fragment of an engineered human antibody.
T. J. Norman, D. Parker, L. Royle, A. Harrison, P. Antoniw and D. J. King, J. Chem. Soc., Chem. Commun., 1995, 1877 DOI: 10.1039/C39950001877
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