Chiral amine–silyl triflate complex mediated asymmetric intramolecular Michael–aldol reaction via a novel enantioselective enol silylation process

Abstract

An asymmetric intramolecular Michael–aldol reaction of a C_s symmetric ketone using chiral amine and silyl triflate is described as a new methodology of chiral induction; nonracemic tricyclic cyclobutanes were obtained from a 4-substituted cyclohexanone in high yields with moderate enantioselectivities in one step.