Issue 1, 2003
From the journal:

Chemical Communications

Chirality transfer during alkylation of chiral amides

Takeo Kawabata,*a   Orhan Öztürk,a   Jianyong Chena  and  Kaoru Fujia  

* Corresponding authors

a Institute for Chemical Research, Kyoto University, Uji, Kyoto-, Japan
E-mail: kawabata@scl.kyoto-u.ac.jp

Abstract

Chiral amides derived from O-methyl mandelic acid and achiral amines underwent enantioselective α-methylation on treatment with LTMP followed by addition of methyl iodide; chirality transfer from an undeprotonated chiral amide into an achiral enolate in a mixed aggregate is supposed to be responsible for the asymmetric induction.

Graphical abstract: Chirality transfer during alkylation of chiral amides

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Article information

DOI
https://doi.org/10.1039/B209736B
Article type
Communication
Submitted
07 Oct 2002
Accepted
25 Nov 2002
First published
06 Dec 2002

Chem. Commun., 2003, 162-163

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Chirality transfer during alkylation of chiral amides

T. Kawabata, O. Öztürk, J. Chen and K. Fuji, Chem. Commun., 2003, 162 DOI: 10.1039/B209736B

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