Issue 42, 2007
From the journal:

Chemical Communications

Inhibition of SARS coronavirus helicase by bismuth complexes†

Nan Yang,a   Julian A. Tanner,b   Zai Wang,b   Jian-Dong Huang,b   Bo-Jian Zheng,c   Nianyong Zhua  and  Hongzhe Sun*a  

* Corresponding authors

a Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P.R. China
E-mail: hsun@hku.hk
Fax: (+852)2857 1586

b Department of Biochemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P.R. China

c Department of Microbiology, The University of Hong Kong, Pokfulam Road, Hong Kong, P.R. China

Abstract

A series of bismuth complexes were synthesized and characterized, and most of them exhibited inhibition against the SARS coronavirus helicase ATPase and duplex-unwinding activities at micromolar concentrations.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes

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Article information

DOI
https://doi.org/10.1039/B709515E
Article type
Communication
Submitted
22 Jun 2007
Accepted
06 Aug 2007
First published
16 Aug 2007

Chem. Commun., 2007, 4413-4415

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Inhibition of SARS coronavirus helicase by bismuth complexes

N. Yang, J. A. Tanner, Z. Wang, J. Huang, B. Zheng, N. Zhu and H. Sun, Chem. Commun., 2007, 4413 DOI: 10.1039/B709515E

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