Issue 44, 2009
From the journal:

Chemical Communications

Asymmetric construction of quaternary stereocenters by direct organocatalytic amination of 3-substituted oxindoles†

Zi-Qing Qian,a   Feng Zhou,a   Tai-Ping Du,b   Bo-Lun Wang,a   Miao Ding,a   Xiao-Li Zhaoa  and  Jian Zhou*a  

* Corresponding authors

a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, P. R. China
E-mail: jzhou@chem.ecnu.edu.cn
Fax: +86 21-6223-4560
Tel: +86 21-6223-4560

b College of Pharmaceutical Sciences, Southwest University, 2N. Tiansheng Road, Beibei, P. R. China

Abstract

Quinidine derivative (QD)2PYR was found to catalyze the asymmetric direct amination of unprotected prochiral 3-oxindole with DIAD to construct quaternary stereocenters at the C3 position with excellent enantioselectivity.

Graphical abstract: Asymmetric construction of quaternary stereocenters by direct organocatalytic amination of 3-substituted oxindoles

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Article information

DOI
https://doi.org/10.1039/B915257A
Article type
Communication
Submitted
27 Jul 2009
Accepted
10 Sep 2009
First published
25 Sep 2009

Chem. Commun., 2009, 6753-6755

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Asymmetric construction of quaternary stereocenters by direct organocatalytic amination of 3-substituted oxindoles

Z. Qian, F. Zhou, T. Du, B. Wang, M. Ding, X. Zhao and J. Zhou, Chem. Commun., 2009, 6753 DOI: 10.1039/B915257A

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