Issue 6, 2010
From the journal:

Chemical Communications

Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes†

Adrian Fegan,a   Pravin S. Shirude,a   Liming Yingb  and  Shankar Balasubramanian*ac  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: sb10031@cam.ac.uk
Fax: +44 1223 336913
Tel: +44 1223 336347

b Molecular Medicine, National Heart and Lung Institute and Chemical Biology Centre, Imperial College London, London, UK

c School of Clinical Medicine, University of Cambridge, Cambridge, UK

Abstract

FRET analysis has been used to examine the folded conformations and differing kinetic stabilities of two DNA G-quadruplexes (c-kit 1 and c-kit 2) derived from sequences found in the promoter of the c-kit proto-oncogene.

Graphical abstract: Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes

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Article information

DOI
https://doi.org/10.1039/B920680A
Article type
Communication
Submitted
06 Oct 2009
Accepted
19 Nov 2009
First published
10 Dec 2009

Chem. Commun., 2010,46, 946-948

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Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes

A. Fegan, P. S. Shirude, L. Ying and S. Balasubramanian, Chem. Commun., 2010, 46, 946 DOI: 10.1039/B920680A

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