Issue 7, 2010
From the journal:

Chemical Communications

Enzymatically degradable heparin-polyethylene glycol gels with controlled mechanical properties†

Mikhail V. Tsurkan,ab   Kandice R. Levental,ab   Uwe Freudenbergab  and  Carsten Werner*ab  

* Corresponding authors

a Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden Hohe Str. 6, 01069 Dresden, Germany
E-mail: werner@ipfdd.de
Fax: (+)49 351 4658 533

b Technische Universität Dresden, Center for Regenerative Therapies Dresden, Tatzberg 47-49, Dresden, Germany

Abstract

A new class of biodegradable materials was prepared by combining polyethylene glycol, heparin, and a matrix metalloproteinase-cleavable peptide sequence into a well-defined hydrogel network which mimics native extracellular matrices in its ability to provide mechanical support and chemical signals as well as elicit a dynamic reciprocal response.

Graphical abstract: Enzymatically degradable heparin-polyethylene glycol gels with controlled mechanical properties

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Article information

DOI
https://doi.org/10.1039/B921616B
Article type
Communication
Submitted
16 Oct 2009
Accepted
25 Nov 2009
First published
16 Dec 2009

Chem. Commun., 2010,46, 1141-1143

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Enzymatically degradable heparin-polyethylene glycol gels with controlled mechanical properties

M. V. Tsurkan, K. R. Levental, U. Freudenberg and C. Werner, Chem. Commun., 2010, 46, 1141 DOI: 10.1039/B921616B

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