Hybrid bioinorganic insulinamyloid fibrils

Abstract

Herein we report a method to functionalize in vitro grown insulin amyloid fibrils with various inorganic materials. The counterion of the positively charged amyloid fibril is exchanged with anions from various salts; subsequent addition of appropriate cations results in functionalization of the amyloid fibril. We demonstrate the formation of apatite and platinum complex structures ordered by the amyloid template.