Issue 25, 2010
From the journal:

Chemical Communications

Iron(ii)–bis(isonitrile) complexes: novel catalysts in asymmetric transfer hydrogenations of aromatic and heteroaromatic ketones†

Anu Naik,a   Tapan Majia  and  Oliver Reiser*a  

* Corresponding authors

a Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany
E-mail: oliver.reiser@chemie.uni-regensburg.de
Fax: +49 941 943 4121
Tel: +49 941 943 4631

Abstract

Chiral iron(II)−bis(isonitrile) complexes catalyse the transfer hydrogenation of aromatic ketones with enantioselectivities up to 91% ee, most likely via hydride transfer through imine intermediates, generated by in situ reduction of the isonitrile ligands, whereas iron acts as a Lewis acid to activate the ketone.

Graphical abstract: Iron(ii)–bis(isonitrile) complexes: novel catalysts in asymmetric transfer hydrogenations of aromatic and heteroaromatic ketones

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DOI
https://doi.org/10.1039/C0CC00508H
Article type
Communication
Submitted
20 Mar 2010
Accepted
06 May 2010
First published
20 May 2010

Chem. Commun., 2010,46, 4475-4477

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Iron(II)–bis(isonitrile) complexes: novel catalysts in asymmetric transfer hydrogenations of aromatic and heteroaromatic ketones

A. Naik, T. Maji and O. Reiser, Chem. Commun., 2010, 46, 4475 DOI: 10.1039/C0CC00508H

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