Issue 32, 2010
From the journal:

Chemical Communications

Enhanced gene transfection capability of polyethylenimine by incorporating boronic acidgroups†

Qi Peng,a   Fujie Chen,a   Zhenlin Zhong*a  and  Renxi Zhuoa  

* Corresponding authors

a Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, China
E-mail: zlzhong@whu.edu.cn
Fax: (+86) 27-6875-4509
Tel: (+86) 27-6875-4509

Abstract

Phenylboronic acid-modified PEI was prepared by the reaction of 1800 Da PEI with 4-(bromomethyl)phenylboronic acid. It is much more effective than unmodified PEI for gene delivery. The covalently incorporated boronic acid groups achieve the greatly enhanced gene delivery efficiency partially through improving condensation ability to DNA, and partially through facilitating cell uptake due to interaction with ligands in cells.

Graphical abstract: Enhanced gene transfection capability of polyethylenimine by incorporating boronic acid groups

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Article information

DOI
https://doi.org/10.1039/C0CC00877J
Article type
Communication
Submitted
12 Apr 2010
Accepted
08 Jun 2010
First published
13 Jul 2010

Chem. Commun., 2010,46, 5888-5890

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Enhanced gene transfection capability of polyethylenimine by incorporating boronic acid groups

Q. Peng, F. Chen, Z. Zhong and R. Zhuo, Chem. Commun., 2010, 46, 5888 DOI: 10.1039/C0CC00877J

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