Issue 37, 2010
From the journal:

Chemical Communications

Complete surface control of peptide nanospheres with detachable and attachable polymer brush layers†

Tomonori Waku,ad   Masahiro Matsumoto,a   Michiya Matsusakiab  and  Mitsuru Akashi*ac  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita 565-0871, Japan
E-mail: akashi@chem.eng.osaka-u.ac.jp
Fax: +81-6-6879-7359
Tel: +81-6-6879-7356

b Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi-shi 332-0012, Japan

c Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi-shi 332-0012, Japan

d Current affiliation: Department of Bio-molecular Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo, Kyoto 606-8585, Japan

Abstract

The surfaces of biodegradable peptide nanospheres with density-controllable poly(ethylene glycol) (PEG) brush layers were amenable to high levels of control, from hydrophilic ‘stealth’ properties to hydrophobic adsorptive properties depending on the PEG density in response to environmental conditions – ‘intelligent’ properties that are expected to be useful for novel drug delivery systems.

Graphical abstract: Complete surface control of peptide nanospheres with detachable and attachable polymer brush layers

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Article information

DOI
https://doi.org/10.1039/C0CC01051K
Article type
Communication
Submitted
21 Apr 2010
Accepted
28 Jul 2010
First published
25 Aug 2010

Chem. Commun., 2010,46, 7025-7027

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Complete surface control of peptide nanospheres with detachable and attachable polymer brush layers

T. Waku, M. Matsumoto, M. Matsusaki and M. Akashi, Chem. Commun., 2010, 46, 7025 DOI: 10.1039/C0CC01051K

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