Issue 39, 2010
From the journal:

Chemical Communications

Enhanced G4-DNA binding of 5,10,15,20 (N-propyl-4-pyridyl) porphyrin (TPrPyP4): A comparative study with TMPyP4†

Susanna Cogoia  and  Luigi E. Xodo*a  

* Corresponding authors

a Department of Biomedical Science and Technology, University of Udine, 33100 Udine, Italy
E-mail: luigi.xodo@uniud.it
Fax: +39 0432 494301
Tel: +39 0432 494395

Abstract

The cationic porphyrin TPrPyP4, with four propyl substituents in the pyridinium rings, is evaluated in vitro by spectroscopic and polymerase-stop assays as a G4-DNA ligand and in cultured cells as a modulator of gene transcription. A comparison with the widely used TMPyP4 is presented.

Graphical abstract: Enhanced G4-DNA binding of 5,10,15,20 (N-propyl-4-pyridyl) porphyrin (TPrPyP4): A comparative study with TMPyP4

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Article information

DOI
https://doi.org/10.1039/C0CC01912G
Article type
Communication
Submitted
16 Jun 2010
Accepted
17 Aug 2010
First published
06 Sep 2010

Chem. Commun., 2010,46, 7364-7366

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Enhanced G4-DNA binding of 5,10,15,20 (N-propyl-4-pyridyl) porphyrin (TPrPyP4): A comparative study with TMPyP4

S. Cogoi and L. E. Xodo, Chem. Commun., 2010, 46, 7364 DOI: 10.1039/C0CC01912G

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