Issue 42, 2010
From the journal:

Chemical Communications

Gold(i)/Zn(ii) catalyzed tandem hydroamination/annulation reaction of 4-yne-nitriles†

Ayhan S. Demir,*a   Mustafa Emrullahoğluab  and  Kerem Burana  

* Corresponding authors

a Department of Chemistry, Middle East Technical University, 06531 Ankara, Turkey
E-mail: asdemir@metu.edu.tr
Tel: 0090 (0)312 210 32 42

b The İzmir Institute of Technology Gülbahçe Köyü, Urla, 35430 Izmir, Turkey

Abstract

The tandem hydroamination–annulation reaction of 4-pentyne-nitriles in the presence of amine nucleophiles and a cooperatively operating catalyst system, consisting of Ph3PAuCl and Zn(ClO4)2, provides an efficient route to 2-aminopyrroles. Two regioisomeric 2-aminopyrroles were formed in moderate to good yields.

Graphical abstract: Gold(i)/Zn(ii) catalyzed tandem hydroamination/annulation reaction of 4-yne-nitriles

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Article information

DOI
https://doi.org/10.1039/C0CC02357D
Article type
Communication
Submitted
04 Jul 2010
Accepted
01 Sep 2010
First published
21 Sep 2010

Chem. Commun., 2010,46, 8032-8034

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Gold(I)/Zn(II) catalyzed tandem hydroamination/annulation reaction of 4-yne-nitriles

A. S. Demir, M. Emrullahoğlu and K. Buran, Chem. Commun., 2010, 46, 8032 DOI: 10.1039/C0CC02357D

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