Issue 48, 2010
From the journal:

Chemical Communications

Structure-based design of selective high-affinity telomeric quadruplex-binding ligands†

Caterina Maria Lombardo,a   Iria Sánchez Martínez,a   Shozeb Haider,a   Valérie Gabelica,b   Edwin De Pauw,b   John E. Mosesc  and  Stephen Neidle*a  

* Corresponding authors

a CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK
E-mail: stephen.neidle@pharmacy.ac.uk
Tel: +44 (0)20 7753 5969

b Physical Chemistry and Mass Spectrometry Laboratory, Department of Chemistry, University of Liege, B-4000 Liege, Belgium

c The School of Chemistry, University of Nottingham, University Park, Nottingham, UK

Abstract

A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.

Graphical abstract: Structure-based design of selective high-affinity telomeric quadruplex-binding ligands

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Article information

DOI
https://doi.org/10.1039/C0CC02917C
Article type
Communication
Submitted
30 Jul 2010
Accepted
06 Oct 2010
First published
29 Oct 2010

Chem. Commun., 2010,46, 9116-9118

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Structure-based design of selective high-affinity telomeric quadruplex-binding ligands

C. M. Lombardo, I. S. Martínez, S. Haider, V. Gabelica, E. De Pauw, J. E. Moses and S. Neidle, Chem. Commun., 2010, 46, 9116 DOI: 10.1039/C0CC02917C

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