Issue 1, 2011
From the journal:

Chemical Communications

Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and esters†‡§

Ina Wilkening,a   Giuseppe del Signorea  and  Christian P. R. Hackenberger*a  

* Corresponding authors

a Freie Universität Berlin, Institut für Chemie und Biochemie, Takustr. 3, 14195 Berlin, Germany
E-mail: hackenbe@chemie.fu-berlin.de
Fax: +49 30 838 52551
Tel: +49 30 838 52451

Abstract

The Staudinger reaction of unprotected azido-peptides with silylated phosphinic acids and esters on the solid support offers a straightforward acid-free entry to different phosphonamidate peptide esters or acids under mild conditions in high purity and yield.

Graphical abstract: Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and esters

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Article information

DOI
https://doi.org/10.1039/C0CC02472D
Article type
Communication
Submitted
09 Jul 2010
Accepted
06 Aug 2010
First published
07 Sep 2010

Chem. Commun., 2011,47, 349-351

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Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and esters

I. Wilkening, G. D. Signore and C. P. R. Hackenberger, Chem. Commun., 2011, 47, 349 DOI: 10.1039/C0CC02472D

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