Issue 2, 2011
From the journal:

Chemical Communications

Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation†

Robert B. P. Elmes,a   Marialuisa Erby,b   Suzanne M. Cloonan,b   Susan J. Quinn,*c   D. Clive Williams*b  and  Thorfinnur Gunnlaugsson*a  

* Corresponding authors

a School of Chemistry, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland
E-mail: gunnlaut@tcd.ie
Fax: +353 1 671 2826
Tel: +353 1 896 3459

b School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
E-mail: clive.williams@tcd.ie
Fax: +353 1 8963130
Tel: +353 1 8962596

c School of Chemistry and Chemical Biology, Centre for Chemical Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland

Abstract

The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.

Graphical abstract: Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation

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Article information

DOI
https://doi.org/10.1039/C0CC04303F
Article type
Communication
Submitted
08 Oct 2010
Accepted
02 Nov 2010
First published
22 Nov 2010

Chem. Commun., 2011,47, 686-688

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Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation

R. B. P. Elmes, M. Erby, S. M. Cloonan, S. J. Quinn, D. C. Williams and T. Gunnlaugsson, Chem. Commun., 2011, 47, 686 DOI: 10.1039/C0CC04303F

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