Issue 11, 2011
From the journal:

Chemical Communications

Anaerobic conditions to reduce oxidation of proteins and to accelerate the copper-catalyzed “Click” reaction with a water-soluble bis(triazole) ligand†

Amit Kumar,a   King Lib  and  Chengzhi Cai*a  

* Corresponding authors

a Department of Chemistry, University of Houston, Houston, USA
E-mail: cai@uh.edu
Fax: +1 713 743 2709
Tel: +1 713 743 2710

b Department of Radiology, The Methodist Hospital Research Institute, Houston, USA

Abstract

Oxidation of protein (bovine albumin serum) by air still occurred under the copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction conditions even in the presence of a Cu(I)-stabilizing tris(triazole) ligand. Anaerobic conditions not only avoided the oxidation of the protein, but also greatly accelerated the CuAAC reaction using a water-soluble bis(triazole) Cu(I) ligand.

Graphical abstract: Anaerobic conditions to reduce oxidation of proteins and to accelerate the copper-catalyzed “Click” reaction with a water-soluble bis(triazole) ligand

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Article information

DOI
https://doi.org/10.1039/C0CC05376G
Article type
Communication
Submitted
05 Dec 2010
Accepted
12 Jan 2011
First published
31 Jan 2011

Chem. Commun., 2011,47, 3186-3188

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Anaerobic conditions to reduce oxidation of proteins and to accelerate the copper-catalyzed “Click” reaction with a water-soluble bis(triazole) ligand

A. Kumar, K. Li and C. Cai, Chem. Commun., 2011, 47, 3186 DOI: 10.1039/C0CC05376G

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